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Common side effects of Skelaxin include headache, nausea, vomiting, and nervousness Metaxalone, sold under the brand name Skelaxin, is a muscle relaxant medication used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Common side effects of Skelaxin include headache, nausea, vomiting, and nervousness Metaxalone, sold under the brand name Skelaxin, is a muscle relaxant medication used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures Skelaxin is a prescription medicine used to treat the symptoms of musculoskeletal pain. 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